{"product_id":"hyalubrix-1-x-2-ml","title":"Hyalubrix 1x 2.0 ml","description":"\u003ch2\u003eSolution with the sodium salt of hyaluronic acid for intraarticular use\u003c\/h2\u003e\n\n\u003cp\u003e\u003cstrong\u003ePre-filled syringe\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003ch3\u003eProduct description\u003c\/h3\u003e\n\u003cp\u003eHYALUBRIX is a sterile, viscoelastic solution containing the sodium salt of hyaluronic acid, obtained by bacterial fermentation from a high molecular weight fraction.\u003c\/p\u003e\n\n\u003cp\u003eHyaluronic acid is an endogenous polysaccharide of the glycosaminoglycan family found in cartilage and joint fluid. It is continuously released into the joint and is one of the main components of joint fluid, giving it its characteristic viscosity and elasticity. These properties are crucial for the lubricating and shock-absorbing function of the fluid in healthy joints to protect cartilage and soft tissues from mechanical injury.\u003c\/p\u003e\n\n\u003cp\u003eTraumatic and degenerative joint changes lead to a deficiency of hyaluronic acid and a loss of viscosity in the joint fluid, which in turn impairs joint function and causes painful symptoms. Numerous data in the literature show that intraarticular injection of hyaluronic acid can restore the viscoelastic properties of the joint fluid.\u003c\/p\u003e\n\n\u003cp\u003eHYALUBRIX serves as a temporary replacement of joint fluid in patients with degenerative or mechanical joint disease that causes changes in the functional properties of the joint fluid. Weekly intraarticular injections of HYALUBRIX provide pain relief and improvement of joint function for up to six months in patients with degenerative or mechanical joint changes.\u003c\/p\u003e\n\n\u003ch3\u003eComposition\u003c\/h3\u003e\n\u003cp\u003eMain ingredient: sodium salt of hyaluronic acid 1.5%\u003c\/p\u003e\n\n\u003cp\u003eOther ingredients: sodium chloride, disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate, water for injection.\u003c\/p\u003e\n\n\u003ch3\u003eAreas of application\u003c\/h3\u003e\n\u003cp\u003eHYALUBRIX is indicated for the treatment of pain and improvement of joint function in patients with degenerative or mechanical joint changes of the knee, hip, shoulder, ankle, and thumb saddle joint.\u003c\/p\u003e\n\n\u003cp\u003eThe product is indicated for the treatment of persistent pain after initial failure of analgesics or failure or intolerance of nonsteroidal anti-inflammatory drugs.\u003c\/p\u003e\n\n\u003ch3\u003eIntended use\u003c\/h3\u003e\n\u003cp\u003eHYALUBRIX is a temporary joint fluid substitute and must be injected intraarticularly.\u003c\/p\u003e\n\n\u003ch3\u003eDosage and method of administration\u003c\/h3\u003e\n\u003cp\u003eHYALUBRIX is intended exclusively for intra-articular injection.\u003c\/p\u003e\n\n\u003cp\u003eThe product may only be used by licensed physicians (e.g., orthopedists, rheumatologists, specialists in physical and rehabilitative medicine, radiologists, sports medicine doctors, etc.).\u003c\/p\u003e\n\n\u003cp\u003eThe injection must be strictly intra-articular. The intra-articular injection must be performed according to the usual standard technique, taking anatomical conditions into account. For the hip, shoulder, and other less accessible joints, sonographic or fluoroscopic guidance is recommended.\u003c\/p\u003e\n\n\u003cp\u003eInject HYALUBRIX into the affected joint at weekly intervals over three weeks using a suitable sterile needle (e.g., 18 or 20 G).\u003c\/p\u003e\n\n\u003cp\u003eIf necessary, treatment can be repeated. However, no systematically collected data are available for this.\u003c\/p\u003e\n\n\u003cp\u003eClinical data demonstrate the efficacy of HYALUBRIX for up to six months. If clinically necessary, treatment can be repeated from three months after the first treatment cycle.\u003c\/p\u003e\n\n\u003cp\u003eAll rules of aseptic technique and injection procedure must be observed.\u003c\/p\u003e\n\n\u003cp\u003eAny joint effusion must be removed before use.\u003c\/p\u003e\n\n\u003ch3\u003eContraindications\u003c\/h3\u003e\n\u003cp\u003eDo not administer to patients with known hypersensitivity to any of the product components.\u003c\/p\u003e\n\n\u003cp\u003eDo not administer if infections or skin diseases are present at the injection site.\u003c\/p\u003e\n\n\u003cp\u003eDo not administer to patients with active synovitis.\u003c\/p\u003e\n\n\u003ch3\u003eUse in certain patient groups\u003c\/h3\u003e\n\u003cp\u003eThe safety and efficacy of HYALUBRIX in pregnant or breastfeeding women or patients under 18 years of age have not been studied. Therefore, use in these patient groups is contraindicated.\u003c\/p\u003e\n\n\u003ch3\u003eWarnings and precautions\u003c\/h3\u003e\n\u003cp\u003eDo not use if the packaging is damaged.\u003c\/p\u003e\n\n\u003cp\u003eDo not use the product after the expiration date indicated on the packaging. The expiration date applies to the product stored in the original packaging at a temperature not exceeding 25 °C.\u003c\/p\u003e\n\n\u003cp\u003eThe syringe is intended for single use only, i.e., for one injection in one patient. Inject the syringe contents into only one joint.\u003c\/p\u003e\n\n\u003cp\u003eIn the first 24 hours after the injection, patients can carry out all daily activities. However, it is recommended not to overload the treated joint.\u003c\/p\u003e\n\n\u003cp\u003eThe prepared syringe must be disposed of immediately after each use, regardless of whether the entire solution has been administered.\u003c\/p\u003e\n\n\u003cp\u003eWhen reprocessing and\/or reusing this product, Fidia Farmaceutici can no longer guarantee the effectiveness, functionality, material structure, purity, or sterility of the product. Reuse may lead to illness, infection, and\/or serious injury to the patient or user.\u003c\/p\u003e\n\n\u003cp\u003eAfter use, dispose of the product according to national regulations.\u003c\/p\u003e\n\n\u003cp\u003eKeep out of reach of children.\u003c\/p\u003e\n\n\u003ch3\u003eSide effects\u003c\/h3\u003e\n\u003cp\u003eAt the injection site, local pain, swelling, a feeling of warmth, and redness may occasionally occur. Such symptoms are generally mild and subside. After the intra-articular injection, applying an ice pack to the treated joint for five to ten minutes may reduce the frequency of these symptoms.\u003c\/p\u003e\n\n\u003cp\u003eIn people with hypersensitivity to the product components, local or systemic allergic reactions may occur.\u003c\/p\u003e\n\n\u003cp\u003eOccasionally, stronger inflammatory reactions (sometimes with sodium pyrophosphate crystals) have been reported in connection with intra-articular injections of hyaluronate.\u003c\/p\u003e\n\n\u003cp\u003eAs with any intra-articular treatment, septic arthritis may rarely occur if general precautions for injections are not observed or if the injection site is not sterile.\u003c\/p\u003e\n\n\u003ch3\u003eInteractions\u003c\/h3\u003e\n\u003cp\u003eThe product must not be used together with disinfectants containing quaternary ammonium salts, as hyaluronic acid may precipitate in their presence.\u003c\/p\u003e\n\n\u003cp\u003eTo avoid possible interactions, the simultaneous use of HYALUBRIX with other products administered intra-articularly should be avoided.\u003c\/p\u003e\n\n\u003ch3\u003eStorage\u003c\/h3\u003e\n\u003cp\u003eStore at a temperature not exceeding 25 °C.\u003c\/p\u003e\n\n\u003ch3\u003eDosage forms\u003c\/h3\u003e\n\u003cp\u003eBox with one prefilled syringe containing a solution of 30 mg\/2 ml sodium salt of hyaluronic acid.\u003c\/p\u003e\n\n\u003cp\u003eThe heat-sterilized syringe has a protective device and is airtight packed in a blister pack.\u003c\/p\u003e\n\n\u003cp\u003eAvailable package sizes:\u003c\/p\u003e\n\u003cul\u003e\n  \u003cli\u003eBox with one prefilled syringe in a blister pack\u003c\/li\u003e\n  \u003cli\u003eBox with three prefilled syringes, each in a blister pack.\u003c\/li\u003e\n  \u003cli\u003eBox with 50 prefilled syringes (for healthcare facilities only)\u003c\/li\u003e\n  \u003cli\u003eBox with 100 prefilled syringes (for healthcare facilities only)\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eThe package does not contain needles.\u003c\/p\u003e\n\n\u003ch3\u003eManufacturer\u003c\/h3\u003e\n\u003cp\u003eFIDIA Farmaceutici S.p.A.\u003cbr\u003e\nVia Ponte della Fabbrica 3\/A\u003cbr\u003e\n35031 Abano Terme (PD), Italy\u003c\/p\u003e\n\n\u003ch3\u003eStatus of the information in the instructions for use:\u003c\/h3\u003e\n\u003cp\u003eMarch 2021\u003c\/p\u003e","brand":"Fidia Pharma GmbH","offers":[{"title":"Default Title","offer_id":47355879719252,"sku":"120","price":21.8,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0786\/8756\/8212\/files\/hyalubrix-1x-20-ml-fidia-pharma-gmbh-gelenkspritzen-stakonmed-2067480.jpg?v=1777230013","url":"https:\/\/stakonmed.com\/products\/hyalubrix-1-x-2-ml","provider":"StakonMed","version":"1.0","type":"link"}